disease

MULTIPLE SCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MULTIPLE SCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2461Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	EGFR, MTOR, SQSTM1, JUN, TP53, VEGF, AMYLOID, PARP1
Therapeutic Agents	DIMETHYL FUMARATE, METFORMIN
KG Connections	646 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"associated"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"protects against"| NEURODEGENERATION_1["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| NEUROINFLAMMATION_2["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| RIPK1["RIPK1"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    ALS["ALS"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    MICROGLIA["MICROGLIA"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    style MULTIPLE_SCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (748)

Target	Relation	Type	Str
NEURON	activates	cell_type	0.86
microglia	associated_with	cell_type	0.80
ASTROCYTES	activates	cell_type	0.72
PARKINSON'S DISEASE	associated_with	disease	0.72
MICROGLIAL ACTIVATION	regulates	phenotype	0.70
TH	regulates	gene	0.70
PARKIN	causes	gene	0.65
PARKINSON	causes	disease	0.65
PARKINSON'S	causes	disease	0.65
PARKINSON'S DISEASE	causes	disease	0.65
NEURODEGENERATION	processes	disease	0.65
STING	interacts_with	gene	0.65
NEURODEGENERATION	impairs	disease	0.65
TAU	phosphorylates	gene	0.65
TRAUMATIC BRAIN INJURY	impairs	disease	0.65
NEURODEGENERATION	promotes	disease	0.65
PARKIN	treats	gene	0.65
PARKINSON	treats	disease	0.65
PARKINSON'S DISEASE	treats	disease	0.65
NLRP3	regulates	gene	0.65
SYNAPTIC PLASTICITY	stabilizes	phenotype	0.65
APOPTOSIS	produces	phenotype	0.65
AGING	produces	phenotype	0.65
UNFOLDED PROTEIN RESPONSE	causes	pathway	0.65
DEMYELINATION	degrades	phenotype	0.65
NEURODEGENERATION	exacerbates	disease	0.65
NRF2 PATHWAY	activates	pathway	0.65
OLIGODENDROCYTE	associated_with	cell_type	0.60
NEURODEGENERATION	contributes_to	disease	0.60
NEURODEGENERATION	protects_against	disease	0.60
RIPK1	treats	gene	0.60
RIPK3	treats	gene	0.60
NEURON	regulates	cell_type	0.60
NEURODEGENERATION	interacts_with	disease	0.60
STING	causes	gene	0.60
AQP4	activates	gene	0.58
MICROGLIA	activates	cell_type	0.58
NEURON	associated_with	cell_type	0.58
DEMYELINATION	implicated_in	phenotype	0.55
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SPINAL CORD	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
MYELINATION	co_discussed	entity	0.50
OLIGODENDROCYTES	interacts_with	cell_type	0.50
INFLAMMATION	associated_with	process	0.50

Incoming (1713)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
ALS	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
ASTROCYTES	associated_with	cell_type	1.00
IL-6	associated_with	gene	1.00
NF-KB	associated_with	protein	1.00
AKT	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
TNF	associated_with	gene	1.00
TAU	associated_with	protein	0.98
ALZHEIMER'S DISEASE	activates	disease	0.98
MICROGLIA	implicated_in	entity	0.95
DEMYELINATION	involved_in	entity	0.95
MTOR	associated_with	gene	0.90
AQP4	associated_with	entity	0.90
TP53	associated_with	gene	0.82
AMPK	associated_with	gene	0.82
ALZHEIMER'S DISEASE	regulates	disease	0.82
PARKINSON'S DISEASE	activates	disease	0.80
APP	associated_with	gene	0.80
METFORMIN	treats	drug	0.80
MICROBIOTA	implicated_in	biological_process	0.80
TREM2	associated_with	gene	0.74
JUN	associated_with	gene	0.72
BDNF	associated_with	gene	0.72
MAPT	associated_with	gene	0.66
UBIQUITIN	associated_with	protein	0.66
PARKINSON'S DISEASE	regulates	disease	0.66
TARDBP	associated_with	gene	0.66
MICROGLIA	activates	cell_type	0.66
ALZHEIMER	impairs	disease	0.65
ALZHEIMER'S	impairs	disease	0.65
ALZHEIMER'S DISEASE	impairs	disease	0.65
ACHE	reduces	gene	0.65
ENCEPHALITIS	targets	disease	0.65
LEWY BODY	regulates	disease	0.65
ALZHEIMER	phosphorylates	disease	0.65
ALZHEIMER'S DISEASE	phosphorylates	disease	0.65
LEWY BODY DISEASE	regulates	disease	0.65
DEPRESSION	targets	disease	0.65
ASTROCYTE	promotes	cell_type	0.65
ASTROCYTES	promotes	cell_type	0.65
MICROGLIA	promotes	cell_type	0.65
COMPLEMENT PATHWAY	interacts_with	pathway	0.65
GRAY MATTER	causes	brain_region	0.65
ENDOTHELIAL CELLS	activates	cell_type	0.65
CHOLESTEROL	causes	phenotype	0.65
AGING	increases_risk	phenotype	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MULTIPLE SCLEROSIS

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

AI and Machine Learning in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration